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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1971 2
1972 1
1973 2
1974 4
1975 2
1976 1
1977 1
1978 1
1979 3
1981 2
1982 1
1983 1
1984 5
1985 4
1986 2
1990 3
1991 3
1992 8
1993 3
1994 3
1995 2
1996 2
1997 3
1998 4
1999 7
2000 13
2001 16
2002 19
2003 35
2004 31
2005 29
2006 36
2007 34
2008 46
2009 40
2010 66
2011 61
2012 61
2013 68
2014 88
2015 83
2016 61
2017 83
2018 94
2019 92
2020 88
2021 65
2022 43
2023 34
2024 8

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1,217 results

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Page 1
RhoA Signaling in Neurodegenerative Diseases.
Schmidt SI, Blaabjerg M, Freude K, Meyer M. Schmidt SI, et al. Cells. 2022 May 1;11(9):1520. doi: 10.3390/cells11091520. Cells. 2022. PMID: 35563826 Free PMC article. Review.
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction pathways that influence a diverse range of cellular functions. ...Indeed, emerging evidence points toward a role of aberrant RhoA signalin …
Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in regulating multiple signal transduction …
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.
Festa BP, Siddiqi FH, Jimenez-Sanchez M, Won H, Rob M, Djajadikerta A, Stamatakou E, Rubinsztein DC. Festa BP, et al. Neuron. 2023 Jul 5;111(13):2021-2037.e12. doi: 10.1016/j.neuron.2023.04.006. Epub 2023 Apr 26. Neuron. 2023. PMID: 37105172 Free article.
CCR5 and its cognate chemokines are upregulated in the brains of pre-manifesting mouse models for Huntington's disease (HD) and tauopathy, suggesting a pathological role of this microglia-neuronal axis in the early phases of these diseases. ...
CCR5 and its cognate chemokines are upregulated in the brains of pre-manifesting mouse models for Huntington's disease (HD) an …
Huntington's disease.
Shoulson I, Chase TN. Shoulson I, et al. Annu Rev Med. 1975;26:419-36. doi: 10.1146/annurev.me.26.020175.002223. Annu Rev Med. 1975. PMID: 167652 Review. No abstract available.
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Jauhari A, Baranov SV, Suofu Y, Kim J, Singh T, Yablonska S, Li F, Wang X, Oberly P, Minnigh MB, Poloyac SM, Carlisle DL, Friedlander RM. Jauhari A, et al. J Clin Invest. 2020 Jun 1;130(6):3124-3136. doi: 10.1172/JCI135026. J Clin Invest. 2020. PMID: 32182222 Free PMC article.
Cytosolic mtDNA activated the cGAS/STING/IRF3 pathway, stimulating inflammatory cytokine generation. We found that Huntington's disease mice had increased mtDNA release, cGAS activation, and inflammation, all inhibited by exogenous melatonin. ...
Cytosolic mtDNA activated the cGAS/STING/IRF3 pathway, stimulating inflammatory cytokine generation. We found that Huntington's di …
Kinase signalling in Huntington's disease.
Bowles KR, Jones L. Bowles KR, et al. J Huntingtons Dis. 2014;3(2):89-123. doi: 10.3233/JHD-140106. J Huntingtons Dis. 2014. PMID: 25062854 Review.
Alterations in numerous signal transduction pathways and aberrant activity of specific kinases have been identified in multiple cell and mouse models of Huntington's disease (HD), as well as in human HD brain. ...The characterisation of aberrant kinase …
Alterations in numerous signal transduction pathways and aberrant activity of specific kinases have been identified in multipl …
Therapeutic approaches to Huntington disease: from the bench to the clinic.
Caron NS, Dorsey ER, Hayden MR. Caron NS, et al. Nat Rev Drug Discov. 2018 Oct;17(10):729-750. doi: 10.1038/nrd.2018.133. Epub 2018 Sep 21. Nat Rev Drug Discov. 2018. PMID: 30237454 Review.
The 25 years since the identification of the gene responsible for Huntington disease (HD) have stood witness to profound discoveries about the nature of the disease and its pathogenesis. Despite this progress, however, the development of disease-modify …
The 25 years since the identification of the gene responsible for Huntington disease (HD) have stood witness to profound disco …
Could metformin be therapeutically useful in Huntington's disease?
Tang BL. Tang BL. Rev Neurosci. 2020 Apr 28;31(3):297-317. doi: 10.1515/revneuro-2019-0072. Rev Neurosci. 2020. PMID: 31751298 Review.
However, there are also contraindications that associate metformin treatment with cognitive impairment as well as adverse outcomes in Alzheimer's disease and Parkinson's disease animal models. Recently, a beneficial effect of metformin in animal models of Hunting …
However, there are also contraindications that associate metformin treatment with cognitive impairment as well as adverse outcomes in Alzhei …
The role of dopamine in Huntington's disease.
Cepeda C, Murphy KP, Parent M, Levine MS. Cepeda C, et al. Prog Brain Res. 2014;211:235-54. doi: 10.1016/B978-0-444-63425-2.00010-6. Prog Brain Res. 2014. PMID: 24968783 Free PMC article. Review.
Alterations in dopamine (DA) neurotransmission in Parkinson's disease are well known and widely studied. Much less is known about DA changes that accompany and underlie some of the symptoms of Huntington's disease (HD), a dominant inherited neurodegenerative …
Alterations in dopamine (DA) neurotransmission in Parkinson's disease are well known and widely studied. Much less is known about DA …
Neuroprotection by saponins.
Sun A, Xu X, Lin J, Cui X, Xu R. Sun A, et al. Phytother Res. 2015 Feb;29(2):187-200. doi: 10.1002/ptr.5246. Epub 2014 Nov 19. Phytother Res. 2015. PMID: 25408503 Review.
Accumulated evidence suggests that saponins have significant neuroprotective effects on attenuation of central nervous system disorders, such as stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, our understanding of t …
Accumulated evidence suggests that saponins have significant neuroprotective effects on attenuation of central nervous system disorders, suc …
Huntington's disease: a synaptopathy?
Li JY, Plomann M, Brundin P. Li JY, et al. Trends Mol Med. 2003 Oct;9(10):414-20. doi: 10.1016/j.molmed.2003.08.006. Trends Mol Med. 2003. PMID: 14557053 Review.
Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin. ...We also suggest that abnormal synaptic transmission underlies the early symptoms of HD and can contribute to the triggering of cell death in later stages of the disease …
Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin. ...We also suggest that abnormal s …
1,217 results